Protein Synthesis Worksheets

The following protein synthesis worksheets are intended for use with these NGSS standard:

HS-LS1- 1 Construct an explanation based on evidence for how the structure of DNA determines the structure of proteins, which carry out the essential functions of life through systems of specialized cells.


I was once like you, searching all over the web for a decent protein synthesis worksheet! I eventually gave in and decided to create my own. I’d like to share those with you now.

First, I have a very basic protein synthesis practice. It can easily be copied front and back. It includes several challenges. Students begin with the DNA given, and they subsequently determine the mRNA, tRNA, and amino acids. As they move through the worksheet, though, students will be challenged to figure out the missing pieces when they begin with different parts of the problem.

Both of the following resources include a link to a Google Slides version of the file for easy use with Google Classroom.

Learn more about how I plan and teach my DNA Unit here.

One teacher said, “This is great! It is extremely clear and to the point!”

Basic Protein Synthesis Worksheet

Give your students more experience with transcription and translation with this challenge. Each set of questions starts students with a different step in the protein synthesis process, and students will show their understanding of these processes by finding the missing pieces in each situation.

Get it here or through TPT

Next, I also offer a more slow paced guided practice. This resource includes short paragraphs describing transcription and translation. It also walks students through the protein synthesis process in a step by step fashion. I usually start with this one in my class. I set timers and check each students’ work before we move on to the next step.

protein synthesis worksheet

One teacher said, “My 7th grade students LOVED this activity. Great review of protein synthesis.”

Protein Synthesis Guided Practice

If your students need a little more guidance, try this guided practice.
Students will move through protein synthesis one step at a time covering first DNA to mRNA, then mRNA to tRNA. They will practice using the codon chart alone to decipher codons, and then finally students will put it all together to complete full diagrams.

Get it here or through TPT

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Additional Protein Synthesis Resources

If you would like your resources to be included in this list please contact me at laneyleeteaches@gmail.com


My teaching resources have already benefitted the learning of over half a million students. Please pin the image below to help me expand my reach.

protein synthesis worksheet
Laney Lee
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Published by Laney Lee

I'm an American expat in Abu Dhabi seeking new ways to support teachers. I currently teach grade 7 science, run a Teacher Pay Teachers store, and am writing a book on classroom management.

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